Building and exploiting a Digital Twin for the management of drinking water distribution networks

[EN] Digital Twins (DTs) are starting to be exploited to improve the management of water distribution systems (WDSs) and, in the future, they will be crucial for decision making. In this paper, the authors propose several requirements that a DT of a water distribution system should accomplish. Developing a DT is a challenge, and a continuous process of adjustments and learning is required. Due to the advantages of having a DT of the WDS always available, during the last years a strategy to build and maintain a DT of the water distribution network of Valencia (Spain) and its Metropolitan Area (1.6 million inhabitants) was developed. This is one of the first DTs built of a water utility, being currently in operation. The great benefits of their use in the daily operation of the system ensure that they will begin to be usual in the most advanced smart cities.Conejos Fuertes, P.; Martínez Alzamora, F.; Hervás-Carot, M.; Alonso Campos, JC. (2020). Building and exploiting a Digital Twin for the management of drinking water distribution networks. Urban Water Journal. 17(8):704-713. https://doi.org/10.1080/1573062X.2020.1771382S704713178Chacón Ramírez, E., Albarrán, J. C., & Cruz Salazar, L. A. (2019). The Control of Water Distribution Systems as a Holonic System. Studies in Computational Intelligence, 352-365. doi:10.1007/978-3-030-27477-1_27Grieves, M., et al. 2015. Virtually Intelligent Product Systems: Digital and Physical Twins. In Complex Systems Engineering: Theory and Practice, edited by S. Flumerfelt, et al., 175–200. American Institute of Aeronautics and Astronautics.Hatchett, S., J. Uber, D. Boccelli, T. Haxton, R. Janke, A. Kramer, A. Matracia, and S. Panguluri. 2011. “Real-Time Distribution System Modeling: Development, Application, and Insights.” Urban Water Management: Challenges and Oppurtunities - 11thInternational Conference on Computing and Control for the Water Industry, CCWI 2011 July.Kartakis, S., Abraham, E., & McCann, J. A. (2015). WaterBox. Proceedings of the 1st ACM International Workshop on Cyber-Physical Systems for Smart Water Networks. doi:10.1145/2738935.2738939Lin, J., Sedigh, S., & Miller, A. (2009). Towards Integrated Simulation of Cyber-Physical Systems: A Case Study on Intelligent Water Distribution. 2009 Eighth IEEE International Conference on Dependable, Autonomic and Secure Computing. doi:10.1109/dasc.2009.140Qi, Q., & Tao, F. (2018). Digital Twin and Big Data Towards Smart Manufacturing and Industry 4.0: 360 Degree Comparison. IEEE Access, 6, 3585-3593. doi:10.1109/access.2018.2793265Alac, M. (2008). Working with Brain Scans. Social Studies of Science, 38(4), 483-508. doi:10.1177/0306312708089715Shi, Y., Xu, J., & Du, W. (2019). Discussion on the New Operation Management Mode of Hydraulic Engineering Based on the Digital Twin Technique. Journal of Physics: Conference Series, 1168, 022044. doi:10.1088/1742-6596/1168/2/022044Tao, F., Zhang, H., Liu, A., & Nee, A. Y. C. (2019). Digital Twin in Industry: State-of-the-Art. IEEE Transactions on Industrial Informatics, 15(4), 2405-2415. doi:10.1109/tii.2018.2873186Tao, F., Cheng, J., Qi, Q., Zhang, M., Zhang, H., & Sui, F. (2017). Digital twin-driven product design, manufacturing and service with big data. The International Journal of Advanced Manufacturing Technology, 94(9-12), 3563-3576. doi:10.1007/s00170-017-0233-1Tao, F., & Qi, Q. (2019). Make more digital twins. Nature, 573(7775), 490-491. doi:10.1038/d41586-019-02849-1Uber, J., S. Hatchett, S. Hooper, D. Boccelli, H. Woo, and R. Janke. 2014. Water Utility Case Study of Real-Time Network Hydaulic and Water Qualilty Modeling Using EPANET-RTX Libraries. EPA 6007R-14/350 Report. Cincinnati, Ohio: Environmental Protection Agency.Wang, Z., Song, H., Watkins, D. W., Ong, K. G., Xue, P., Yang, Q., & Shi, X. (2015). Cyber-physical systems for water sustainability: challenges and opportunities. IEEE Communications Magazine, 53(5), 216-222. doi:10.1109/mcom.2015.710566

Methodology for flushing pressurised irrigation networks for fertigation and operation maintenance purposes

[EN] Pressurised irrigation networks with a certain degree of automation allow centralized fertigation and maintenance operations such as cleaning subunits and preventing the proliferation of invasive species such as zebra mussels. Until now, there is no methodology that guarantees the total cleaning of the network of a substance in the shortest possible time. In the same way, it does not exist to guarantee reaching all consumption points with a certain concentration of a substance, injecting the minimum possible amount. For that purpose, a general novel methodology has been developed that makes use of the network¿s hydraulic model and parallel multi-objective genetic algorithms to flush the network of a certain substance or to get it to all consumption points in the shortest possible time and supplying a minimum volume. This method assumes that the available pressure at the source is always over a minimum value. The arrival times to the consumption points are minimized and the injected volume is reduced to the minimum of replacement, that is, the volume of the network pipes. The methodology applied to the study case allowed the entire network to be flushed in a minimum time of 2.46 h. On a normal irrigation day, without making any changes to the irrigation schedule the time to completely flush the network is 11.76 h. Furthermore, the injected volume differs greatly from the total volume of the pipes.This study has been partially supported by the ADAPTAMED project (RTI2018-101483-B-I00), funded by the Ministerio de Economia y Competitividad (MINECO) of Spain and with EU FEDER funds.Jiménez Bello, MA.; Alonso Campos, JC.; Manzano Juarez, J.; Martínez Alzamora, F. (2021). Methodology for flushing pressurised irrigation networks for fertigation and operation maintenance purposes. Irrigation Science. 39(3):375-384. https://doi.org/10.1007/s00271-021-00724-437538439

Brane Structure from a Scalar Field in Warped Spacetime

We deal with scalar field coupled to gravity in five dimensions in warped geometry. We investigate models described by potentials that drive the system to support thick brane solutions that engender internal structure. We find analytical expressions for the brane solutions, and we show that they are all linearly stable.Comment: 10 pages, 7 eps figures; version to be published in JCA

Antioxidant responses related to temozolomide resistance in glioblastoma

Ministerio de Ciencia, Innovación y Universidades; Universidad de Málaga CBUA.Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation therapy with concurrent and maintenance chemotherapy with the alkylating agent temozolomide. To date, this drug is the only one that provides a significant survival benefit, albeit modest, as patients end up acquiring resistance to this drug. As a result, tumor progression and recurrence inevitably occur, leading to death. Several factors have been proposed to explain this resistance, including an upregulated antioxidant system to keep the elevated intracellular ROS levels, a hallmark of cancer cells, under control. In this review, we discuss the mechanisms of chemoresistance -including the important role of glioblastoma stem cells-with emphasis on antioxidant defenses and how agents that impair redox balance (i.e.: sulfasalazine, erastin, CB-839, withaferin, resveratrol, curcumin, chloroquine, and hydroxychloroquine) might be advantageous in combined therapies against this type of cancer.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Antiferromagnetic 4-d O(4) Model

We study the phase diagram of the four dimensional O(4) model with first (beta1) and second (beta2) neighbor couplings, specially in the beta2 < 0 region, where we find a line of transitions which seems to be second order. We also compute the critical exponents on this line at the point beta1 =0 (F4 lattice) by Finite Size Scaling techniques up to a lattice size of 24, being these exponents different from the Mean Field ones.Comment: 26 pages LaTeX2e, 7 figures. The possibility of logarithmic corrections has been considered, new figures and tables added. Accepted for publication in Physical Review

Clinical factors associated with discontinuation of ts/bDMARDs in rheumatic patients from the BIOBADASER III registry

Altres ajuts: Spanish Agency of Medicines and Medical Devices (AEMPS); Biogen; Bristol Myers-Squibb (BMS); Celltrion Healthcare; Lilly; Merck; Novartis; Pfizer; Regeneron Pharmaceuticals; Samsung Bioepis.Biologic and targeted synthetic disease-modifying antirheumatic drugs (ts/bDMARDs) play a pivotal role in the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Persistence of therapy provides an index of a drug's overall effectiveness. The objective of the study was to identify factors associated with discontinuation of ts/bDMARDs in a real-world dataset. The study population comprised patients diagnosed with RA, PsA, and AS included in the BIOBADASER registry for whom follow-up data were available until November 2019. Patient features and treatment data were included in the analysis. The Kaplan-Meier method was used to study survival of the different drugs according to the reason for discontinuation. Factors associated with discontinuation were studied using Cox regression models and bivariate and multivariate analyses. P values of less than 0.05 were regarded as statistically significant. The study population comprised 4,752 patients who received a total of 8,377 drugs, of which 4,411 (52.65%) were discontinued. The Kaplan-Meier curves showed that survival for first-line treatment was greater in all 3 groups (p < 0.001). Patients with RA had a greater risk of discontinuation if they were younger (HR, 0.99; 95% CI 0.99-1.00), if they were receiving anti-TNFα agents (HR, 0.61; 95% CI 0.54-0.70), and if they had more comorbid conditions (HR, 1.09; 95% CI 1.00-1.17). Patients with PsA had a higher risk if they were women (HR, 1.36; 95% CI 1.15-1.62) and if they were receiving other ts/bDMARDs (HR, 1.29; 95% CI 1.05-1.59). In patients with AS, risk increased with age (HR, 1.01; 95% CI 1.00-1.02), as did the number of comorbid conditions (HR, 1.27; 95% CI 1.12-1.45). The factors that most affected discontinuation of ts/bDMARDs were line of treatment, age, type of drug, sex, comorbidity and the year of initiation of treatment. The association with these factors differed with each disease, except for first-line treatment, which was associated with a lower risk of discontinuation in all 3 diseases

The U(1)-Higgs Model: Critical Behaviour in the Confinig-Higgs region

We study numerically the critical properties of the U(1)-Higgs lattice model, with fixed Higgs modulus, in the region of small gauge coupling where the Higgs and Confining phases merge. We find evidence of a first order transition line that ends in a second order point. By means of a rotation in parameter space we introduce thermodynamic magnitudes and critical exponents in close resemblance with simple models that show analogous critical behaviour. The measured data allow us to fit the critical exponents finding values in agreement with the mean field prediction. The location of the critical point and the slope of the first order line are accurately given.Comment: 21 text pages. 12 postscript figures available on reques

Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing

Machado-Joseph disease (MJD/SCA3) is a neurodegenerative polyglutamine disorder exhibiting a wide spectrum of phenotypes. The abnormal size of the (CAG)n at ATXN3 explains ~55% of the age at onset variance, suggesting the involvement of other factors, namely genetic modifiers, whose identification remains limited. Our aim was to find novel genetic modifiers, analyse their epistatic effects and identify disease-modifying pathways contributing to MJD variable expressivity. We performed whole-exome sequencing in a discovery sample of four age at onset-concordant and four discordant first-degree relative pairs of Azorean patients, to identify candidate variants which genotypes differed for each discordant pair but were shared in each concordant pair. Variants identified by this approach were then tested in an independent multi-origin cohort of 282 MJD patients. Whole-exome sequencing identified 233 candidate variants, from which 82 variants in 53 genes were prioritized for downstream analysis. Eighteen disease-modifying pathways were identified; two of the most enriched pathways were relevant for the nervous system, namely the neuregulin signaling and the agrin interactions at neuromuscular junction. Variants at PARD3, NFKB1, CHD5, ACTG1, CFAP57, DLGAP2, ITGB1, DIDO1 and CERS4 modulate age at onset in MJD, with those identified in CFAP57, ACTG1 and DIDO1 showing consistent effects across cohorts of different geographical origins. Network analyses of the nine novel MJD modifiers highlighted several important molecular interactions, including genes/proteins previously related with MJD pathogenesis, namely between ACTG1/APOE and VCP/ITGB1. We describe novel pathways, modifiers, and their interaction partners, providing a broad molecular portrait of age at onset modulation to be further exploited as new disease-modifying targets for MJD and related diseases

Quality indicators in radiation oncology: proposal of the Spanish Society of Radiation Oncology (SEOR) for a continuous improvement of the quality of care in oncology.

Purpose Current cancer treatment options include surgical intervention, radiotherapy, and chemotherapy. The quality of the provision of each of them and their effective coordination determines the results in terms of benefit/risk. Regarding the radiation oncology treatments, there are not stabilised quality indicators to be used to perform control and continuous improvement processes for healthcare services. Therefore, the Spanish Society of Radiation Oncology has undertaken a comprehensive project to establish quality indicators for use with the information systems available in most Spanish healthcare services. Methods A two-round Delphi study examines consensus of several possible quality indicators (n = 28) in daily practice. These indicators were defined after a bibliographic search and the assessment by radiation oncology specialists (n = 8). They included aspects regarding treatment equipment, patient preparation, treatment, and follow-up processes and were divided in structure, process, and outcome indicators. Results After the evaluation of the defined quality indicators (n = 28) by an expert panel (38 radiation oncologist), 26 indicators achieved consensus in terms of agreement with the statement. Two quality indicators did not achieve consensus. Conclusions There is a high degree of consensus in Spanish Radiation Oncology specialists on which indicators in routine clinical practice can best measure quality. These indicators can be used to classify services based on several parameters (patients, equipments, complexity of the techniques used, and scientific research). Furthermore, these indicators allow assess our current situation and set improvements’ objectives.pre-print241 K